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Sufferers acquiring other opioids: Discontinue all around-the-clock opioid medicine, then initiate Arymo ER 15mg orally every single eight hours Arymo ER dose when transformed from other opioids or parenteral morphine: Work out 24-hr orallyOpioid-tolerant sufferers: Dose relies on a day-to-day dose of previous opioid analgesic (individualization es